Transcriptomic identification of IL-17/FOS-associated signaling in dartos fascia remodeling of pediatric concealed penis - Takeaways - MDSpire

Transcriptomic identification of IL-17/FOS-associated signaling in dartos fascia remodeling of pediatric concealed penis

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Pediatric concealed penis (CP) is linked to abnormal dartos fascia development and fibrotic remodeling.
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The study utilized RNA-seq to analyze dartos fascia tissues from CP patients and phimosis controls.
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IL-17-related signaling pathways were significantly enriched in CP tissues, indicating a potential role in pathology.
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Key molecules such as IL-17RA, ACT1, FOS, IL-6, and PTGS2 showed increased expression in CP tissues.
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Findings suggest that IL-17/FOS-associated inflammatory remodeling may contribute to reduced tissue compliance in CP.

Frontiers In Pediatrics

by Haiyang Hu, Wenwen Liu, Zhongsong Tu, Jiao Lei, Qiao Wu, Zhangyu Yang, Xiaohou Wu, Peng Jing
July 10, 2026

Frontiers In Pediatrics

Frontiers In Medicine

Jama Network Open

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