N4-acetylcytidine modification bridges metabolic reprogramming and immune evasion in cancer: mechanisms and therapeutic implications - Takeaways - MDSpire

N4-acetylcytidine modification bridges metabolic reprogramming and immune evasion in cancer: mechanisms and therapeutic implications

  • By

  • Ming-Zhu Jin

  • Wen Di

  • June 29, 2026

  • 0 min

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  • 1

    N4-acetylcytidine (ac4C) is a conserved RNA modification that regulates mRNA stability and translation efficiency in cancer.

  • 2

    NAT10-mediated ac4C modification enhances glycolytic enzyme stability, promoting the Warburg effect in cancer cells.

  • 3

    Ac4C modification facilitates immune evasion by upregulating PD-L1 and suppressing T cell function in the tumor microenvironment.

  • 4

    The interplay between metabolic reprogramming and immune evasion in cancer is linked through ac4C modification.

  • 5

    Targeting NAT10 with inhibitors like Remodelin shows preclinical efficacy, especially in combination with immune checkpoint inhibitors.

Original Source(s)

N4-acetylcytidine modification bridges metabolic reprogramming and immune evasion in cancer: mechanisms and therapeutic implications

  • by Ming-Zhu Jin, Wen Di

  • June 29, 2026

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