Adjunctive inhaled antibiotics should not necessarily be considered independently of the systemic antibiotic regimen - Takeaways - MDSpire
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Inhaled Antibiotics as Adjunct Therapy Should Be Evaluated in Conjunction with Systemic Antibiotic Treatments

  • By

  • Patrick M. Honoré

  • Yasser Benkaddour

  • Catherine Yildiz Muscato

  • August 17, 2026

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  • 1

    Lyu et al. conducted a meta-analysis assessing adjunctive inhaled antibiotics for ventilator-associated pneumonia (VAP).

  • 2

    The authors suggest that inhaled antibiotics may be used regardless of the pathogen or systemic antibiotic chosen, a claim that requires further scrutiny.

  • 3

    Studies show that nebulized colistin can lead to systemic absorption, raising concerns about nephrotoxicity.

  • 4

    Pharmacokinetic evidence indicates that nebulized colistin can achieve plasma concentrations similar to intravenous administration.

  • 5

    Caution is advised when using nebulized colistin with intravenous colistin due to potential cumulative systemic exposure and nephrotoxicity risks.

Original Source(s)

Adjunctive inhaled antibiotics should not necessarily be considered independently of the systemic antibiotic regimen

  • by Patrick M. Honoré, Yasser Benkaddour, Catherine Yildiz Muscato

  • August 17, 2026

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