Wogonoside alleviates hyperosmotic stress-induced inflammation and apoptosis in human corneal epithelial cells via PI3K/AKT signaling - Takeaways - MDSpire
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Wogonoside Reduces Inflammation and Cell Death Induced by Hyperosmotic Stress in Human Corneal Epithelial Cells Through the PI3K/AKT Pathway

  • By

  • Yuan Zhong

  • Jian Shi

  • Xi Long

  • Xiyuan Liu

  • Lihao Chen

  • Jun Peng

  • Qinghua Peng

  • May 4, 2026

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  • 1

    Wogonoside (WGS) exhibits anti-inflammatory and cytoprotective effects in human corneal epithelial cells under hyperosmotic stress.

  • 2

    The PI3K/AKT signaling pathway is identified as a key mechanism through which WGS exerts its protective effects against inflammation and apoptosis.

  • 3

    Experimental validation showed that WGS improved cell viability and reduced levels of inflammatory mediators like IL-1β and IL-6 in hyperosmotic conditions.

  • 4

    Molecular docking and dynamics simulations confirmed a stable interaction between WGS and AKT1, supporting its role as a therapeutic target.

  • 5

    The findings suggest that WGS may be a promising candidate for treating hyperosmotic stress-related corneal epithelial injury in dry eye.

Original Source(s)

Wogonoside alleviates hyperosmotic stress-induced inflammation and apoptosis in human corneal epithelial cells via PI3K/AKT signaling

  • by Yuan Zhong, Jian Shi, Xi Long, Xiyuan Liu, Lihao Chen, Jun Peng, Qinghua Peng

  • May 4, 2026

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