Safety and efficacy of port use for CAR T-cell infusion in large B-cell lymphoma - Takeaways - MDSpire
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Safety and effectiveness of implanted ports for CAR T-cell infusion in large B-cell lymphoma

  • By

  • Zachary E. Hunzeker

  • Anath Lionel

  • Xiaowen Sun

  • Lei Feng

  • Sairah Ahmed

  • Amy Ayers

  • Michelly de Castro

  • Jaimole Varghese

  • Karla Ow

  • Taylor Cain

  • Minifrida Santiago

  • Sreekala Nair

  • Jeremy Ramdial

  • Elizabeth J. Shpall

  • Sattva S. Neelapu

  • Paolo Strati

  • October 28, 2026

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  • 1

    This single-center retrospective analysis included 504 patients with large B-cell lymphoma who received CAR T-cell infusion through a port (202 patients) or PICC/CVC (302 patients).

  • 2

    Line-associated infections and prolonged cytopenia rates were comparable between groups, while VTE was less frequent with ports than with PICC/CVCs (3.0% vs 9.3%; P = .006).

  • 3

    Day 30 and day 90 complete metabolic response rates did not differ significantly between the port and PICC/CVC groups.

  • 4

    Median progression-free and overall survival did not differ significantly between patients infused through ports and those infused through PICC/CVCs.

  • 5

    Among 128 patients assessed, CAR T-cell expansion measures did not differ significantly by access type at any assessed time point.

Original Source(s)

Safety and efficacy of port use for CAR T-cell infusion in large B-cell lymphoma

  • by Zachary E. Hunzeker, Anath Lionel, Xiaowen Sun, Lei Feng, Sairah Ahmed, Amy Ayers, Michelly de Castro, Jaimole Varghese, Karla Ow, Taylor Cain, Minifrida Santiago, Sreekala Nair, Jeremy Ramdial, Elizabeth J. Shpall, Sattva S. Neelapu, Paolo Strati

  • October 28, 2026

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