Impact of time from symptom onset to diagnosis in infective endocarditis: insights from the nationwide NIDUS registry - Takeaways - MDSpire
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Effects of Delay from Symptom Onset to Diagnosis in Infective Endocarditis: Findings from the National NIDUS Registry

  • By

  • Mads-Gustav Nebel Hvidt

  • Amna Alhakak

  • Peter Laursen Graversen

  • Katra Hadji-Turdeghal

  • Jacob Eifer Møller

  • Niels Eske Bruun

  • Kasper Karmark Iversen

  • Jonas Agerlund Povlsen

  • Claus Moser

  • Morten Holdgaard Smerup

  • Daniel Faurholt-Jepsen

  • Henning Bundgaard

  • Lauge Østergaard

  • Lars Køber

  • Emil Loldrup Fosbøl

  • August 31, 2026

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  • 1

    Infective endocarditis (IE) is a severe condition with non-specific symptoms, making diagnosis challenging.

  • 2

    The National Danish Endocarditis Study (NIDUS) database includes all patients diagnosed with IE in Denmark from 2016 to 2021.

  • 3

    Patients were categorized based on the interval between symptom onset and diagnosis: ≤7 days, 8–29 days, and ≥30 days.

  • 4

    Microbial aetiology was determined through blood cultures, while surgical indications were based on the 2015 ESC guidelines.

  • 5

    The primary outcome of the study was all-cause mortality at 6 months post-diagnosis, analyzed using multivariable Cox regression.

Original Source(s)

Impact of time from symptom onset to diagnosis in infective endocarditis: insights from the nationwide NIDUS registry

  • by Mads-Gustav Nebel Hvidt, Amna Alhakak, Peter Laursen Graversen, Katra Hadji-Turdeghal, Jacob Eifer Møller, Niels Eske Bruun, Kasper Karmark Iversen, Jonas Agerlund Povlsen, Claus Moser, Morten Holdgaard Smerup, Daniel Faurholt-Jepsen, Henning Bundgaard, Lauge Østergaard, Lars Køber, Emil Loldrup Fosbøl

  • August 31, 2026

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