Beyond the trial: a single-center retrospective review of real-world lupus nephritis management and outcomes - Takeaways - MDSpire

Real-World Management and Outcomes of Lupus Nephritis: Insights from a Single-Center Retrospective Study

  • By

  • Dylan Clapp

  • Mugdha Kulkarni

  • Anthony C. Leonard

  • Manish Anand

  • July 21, 2026

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  • 1

    Lupus nephritis (LN) is a significant complication of systemic lupus erythematosus (SLE), affecting up to 50% of SLE patients.

  • 2

    The study analyzed 66 patients with biopsy-proven LN, revealing a median age of 35 years and a predominance of women and African Americans.

  • 3

    At 12 months, 55% of Class I and II LN and 50% of Class III, IV, and mixed classes showed no response to treatment.

  • 4

    Complications included end-stage renal disease in 17%, infections requiring hospitalization in 41%, and a mortality rate of 14%.

  • 5

    The findings highlight the challenges in managing LN, emphasizing the need for individualized care and awareness of socioeconomic factors.

Original Source(s)

Beyond the trial: a single-center retrospective review of real-world lupus nephritis management and outcomes

  • by Dylan Clapp, Mugdha Kulkarni, Anthony C. Leonard, Manish Anand

  • July 21, 2026

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