Exercise modalities and dose-response for LVEF Improvement in heart failure patients: a systematic review and network meta-analysis - Takeaways - MDSpire

Exercise modalities and dose-response for LVEF Improvement in heart failure patients: a systematic review and network meta-analysis

  • By

  • Fengrui Shi

  • Xiangao Li

  • Hong Wang

  • June 5, 2026

  • 0 min

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  • 1

    Resistance training (RT) significantly enhances left ventricular ejection fraction (LVEF) in heart failure patients, showing the largest treatment effect among exercise modalities.

  • 2

    High-intensity interval training (HIIT) and combined exercise (CE) also improve LVEF, but to a lesser extent than resistance training.

  • 3

    The optimal exercise dosage for LVEF improvement is 500–800 MET-minutes/week, with resistance training effective at lower doses.

  • 4

    A non-linear relationship exists between exercise dose and LVEF improvement, indicating varying thresholds for different exercise types.

  • 5

    These findings support a precision-based rehabilitation strategy focusing on resistance training to optimize cardiac function in heart failure patients.

Original Source(s)

Exercise modalities and dose-response for LVEF Improvement in heart failure patients: a systematic review and network meta-analysis

  • by Fengrui Shi, Xiangao Li, Hong Wang

  • June 5, 2026

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