Ferrets as a model for investigating the impact of chemical agents on cerebral cortical sulcogyrogenesis

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Ferrets exhibit gyrencephalic characteristics, making them suitable for studying sulcogyral development and its relation to neurodevelopmental disorders.
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Neonatal exposure to valproic acid (VPA) alters sulcal infolding in ferrets, reducing it in some areas while increasing it in others, linked to progenitor cell differentiation.
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Lipopolysaccharide (LPS) exposure in ferrets leads to apoptosis of cortical neurons, contributing to abnormal sulcal positioning in the medial and dorsolateral cortices.
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Both VPA and LPS affect subventricular zone progenitors differently, resulting in distinct gyrification abnormalities in ferrets.
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The findings support the use of ferrets as a model to investigate the pathogenesis of neurodevelopmental disorders related to gyrification anomalies.

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