Accelerated metastatic development of primary pulmonary synovial sarcoma despite adherence to multimodal treatment guidelines: a case study

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Primary pulmonary synovial sarcoma (PPSS) accounts for less than 0.5% of all primary lung malignancies and is characterized by an aggressive clinical course.
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PPSS is defined by a chromosomal translocation, t(X;18)(p11;q11), resulting in the fusion of the SYT gene with SSX1 or SSX2.
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A 60-year-old woman with PPSS underwent neoadjuvant chemotherapy and right lower lobectomy, initially showing tumor reduction and no metastatic disease.
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Four months post-surgery, the patient developed widespread metastatic disease, highlighting the aggressive nature of PPSS despite multimodal treatment.
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The case emphasizes the need for improved targeted therapies and broader access to clinical trials for managing rare malignancies like PPSS.

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