Systemic immune-inflammation index as a prognostic biomarker to predict overall survival after primary stereotactic radiosurgery for brain metastases - Takeaways - MDSpire

Systemic immune-inflammation index as a prognostic biomarker to predict overall survival after primary stereotactic radiosurgery for brain metastases

  • By

  • Sukwoo Hong

  • Hirokazu Takami

  • Motoyuki Umekawa

  • Yuki Shinya

  • Hirotaka Hasegawa

  • Mariko Kawashima

  • Yosuke Kitagawa

  • Masashi Nomura

  • Shunsaku Takayanagi

  • Shota Tanaka

  • Nobuhito Saito

  • October 15, 2025

  • 0 min

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  • 1

    Brain metastases are the most prevalent brain tumors in adults, with stereotactic radiosurgery (SRS) being a primary treatment option.

  • 2

    The diagnosis-specific graded prognostic assessment (DS-GPA) has limitations, including subjectivity and lack of objective laboratory markers.

  • 3

    Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) may provide additional prognostic value for patients undergoing SRS.

  • 4

    This study evaluated SII and SIRI as predictors of overall survival and local tumor control duration after primary SRS for brain metastases.

  • 5

    The study utilized a cohort from the GammaKnife database, focusing on patients with adequate pre-SRS complete blood counts.

Original Source(s)

Systemic immune-inflammation index as a prognostic biomarker to predict overall survival after primary stereotactic radiosurgery for brain metastases

  • by Sukwoo Hong, Hirokazu Takami, Motoyuki Umekawa, Yuki Shinya, Hirotaka Hasegawa, Mariko Kawashima, Yosuke Kitagawa, Masashi Nomura, Shunsaku Takayanagi, Shota Tanaka, Nobuhito Saito

  • October 15, 2025

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