Lower limits of CRRT dose-intensity: what does the evidence support? - Takeaways - MDSpire
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Exploring the Minimum CRRT Dose-Intensity: Evidence-Based Insights

  • By

  • Nuttha Lumlertgul

  • Sean M. Bagshaw

  • September 28, 2026

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  • 1

    The systematic review discusses the association between lower CRRT dose-intensity thresholds and mortality, citing specific hazard ratios.

  • 2

    The authors acknowledge discrepancies in hazard ratios reported by different studies, emphasizing the need for clarification from original reports.

  • 3

    Faria and Libório's study was judged to have serious risk of bias due to multiple models presented, affecting the reliability of their estimates.

  • 4

    Recent findings indicate that low and moderate CRRT dose-intensity are associated with lower 90-day mortality compared to higher doses.

  • 5

    The authors highlight ongoing randomized trials aimed at investigating the lower limit of CRRT dose-intensity.

Original Source(s)

Lower limits of CRRT dose-intensity: what does the evidence support?

  • by Nuttha Lumlertgul, Sean M. Bagshaw

  • September 28, 2026

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