Emerging role of ETV4 in colorectal cancer: from molecular mechanisms to clinical implications

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ETV4 is an ETS transcription factor that regulates gene expression and is frequently overexpressed in various cancers, including colorectal cancer (CRC).
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In colorectal cancer, ETV4 overexpression correlates with advanced disease, lymph node metastasis, and poor patient prognosis.
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ETV4 promotes tumor cell proliferation, invasion, and metastasis by activating target genes involved in these processes.
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ETV4 serves as a promising biomarker for CRC diagnosis and prognosis, as well as for adenoma-to-adenocarcinoma progression.
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Targeting ETV4 or its upstream pathways may represent a potential therapeutic strategy for colorectal cancer.

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