A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA - Takeaways - MDSpire

A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA

  • By

  • Tobias Alfvén

  • Tania Reza

  • Alieu Sowe

  • July 15, 2026

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  • 1

    Pediatric vaccines have averted approximately 154 million deaths in the past 50 years, significantly reducing global infant mortality by 40%.

  • 2

    The World Health Organisation's Expanded Programme on Immunisation, established in 1974, increased vaccine coverage in low- and middle-income countries from 5% to over 80%.

  • 3

    Gavi, the Vaccine Alliance, has supported the vaccination of over one billion children in lower-income countries since 2000, averting an estimated 17 million future deaths.

  • 4

    Technological innovations, including combination vaccines and mRNA platforms, have improved immunisation speed and safety, addressing diseases like RSV and malaria.

  • 5

    Robust safety monitoring systems, such as WHO's VigiBase, are essential for maintaining public confidence in vaccines and detecting safety risks.

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