Efficacy of Jishi Shuanghua Granules in preventing radiation-induced esophagitis in non-small cell lung cancer patients undergoing concurrent chemoradiotherapy: protocol for a multicenter, randomized, double-blind, placebo-controlled trial - Takeaways - MDSpire

Efficacy of Jishi Shuanghua Granules in preventing radiation-induced esophagitis in non-small cell lung cancer patients undergoing concurrent chemoradiotherapy: protocol for a multicenter, randomized, double-blind, placebo-controlled trial

  • By

  • Huakang Li

  • Yuanzhen Mi

  • Ke Xu

  • Ming Fan

  • Jun Yin

  • Qiang Li

  • Ziliang Wu

  • Cuicui Gong

  • Yunjing Jia

  • Pengxuan Gu

  • Shanshan Wei

  • Zhonglin Zhang

  • Shuo Zhang

  • Yuanyuan Zheng

  • Bing Lin

  • Jinyi Lang

  • Biao Zhao

  • Meihua Chen

  • June 23, 2026

  • 0 min

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  • 1

    The study aims to evaluate the effectiveness of Jishi Shuanghua Granules in preventing acute radiation-induced esophagitis in NSCLC patients undergoing CCRT.

  • 2

    240 patients with stage III NSCLC will be enrolled and randomly assigned to receive either JSG or a placebo in a double-blind trial.

  • 3

    Primary endpoints include the incidence rates of ARIE and severe ARIE, while secondary endpoints assess pain, dysphagia, and quality of life.

  • 4

    The trial will also explore the mechanisms of JSG through multi-omics analyses, including inflammatory cytokines and gut microbiota.

  • 5

    Jishi Shuanghua Granules consist of 12 herbal constituents and have been used clinically for over ten years to treat CCRT-induced ARIE.

Original Source(s)

Efficacy of Jishi Shuanghua Granules in preventing radiation-induced esophagitis in non-small cell lung cancer patients undergoing concurrent chemoradiotherapy: protocol for a multicenter, randomized, double-blind, placebo-controlled trial

  • by Huakang Li, Yuanzhen Mi, Ke Xu, Ming Fan, Jun Yin, Qiang Li, Ziliang Wu, Cuicui Gong, Yunjing Jia, Pengxuan Gu, Shanshan Wei, Zhonglin Zhang, Shuo Zhang, Yuanyuan Zheng, Bing Lin, Jinyi Lang, Biao Zhao, Meihua Chen

  • June 23, 2026

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