Disease Site-Specific Outcomes in p16-Positive Non-Oropharyngeal Mucosal Head and Neck Cancer - Takeaways - MDSpire
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Outcomes Based on Disease Site in p16-Positive Non-Oropharyngeal Mucosal Head and Neck Squamous Cell Carcinoma

  • By

  • Revadhi C. Chelvarajah

  • Lessandra Y. S. Chee

  • Jie Su

  • Brian O'Sullivan

  • Christopher M. K. L. Yao

  • Enrique Sanz-Garcia

  • Stephen M. Smith

  • Ilan Weinreb

  • Scott Bratman

  • B. C. John Cho

  • Ezra Hahn

  • Andrew Hope

  • Ali Hosni

  • John Kim

  • Andrew McPartlin

  • Nauman Malik

  • Chiaojung Jillian Tsai

  • John de Almeida

  • Anna Spreafico

  • Li Tong

  • Shao Hui Huang

  • John N Waldron

  • March 12, 2026

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  • 1

    The study investigates the prevalence and prognostic significance of p16-positive status in non-oropharyngeal head and neck squamous cell carcinoma (HNSCC).

  • 2

    A total of 3061 non-oropharyngeal HNSCC cases were identified, with p16 testing performed on 466 patients, revealing 91 p16-positive cases.

  • 3

    The study found varying outcomes associated with p16 positivity, with some studies reporting improved survival in laryngeal and hypopharyngeal cancers.

  • 4

    Testing methodologies for p16 and HPV varied, impacting the interpretation of survival benefits in non-oropharyngeal HNSCC.

  • 5

    The research was conducted at a tertiary cancer center, utilizing a comprehensive database to assess p16-positive non-oropharyngeal HNSCC outcomes.

Original Source(s)

Disease Site-Specific Outcomes in p16-Positive Non-Oropharyngeal Mucosal Head and Neck Cancer

  • by Revadhi C. Chelvarajah, Lessandra Y. S. Chee, Jie Su, Brian O'Sullivan, Christopher M. K. L. Yao, Enrique Sanz-Garcia, Stephen M. Smith, Ilan Weinreb, Scott Bratman, B. C. John Cho, Ezra Hahn, Andrew Hope, Ali Hosni, John Kim, Andrew McPartlin, Nauman Malik, Chiaojung Jillian Tsai, John de Almeida, Anna Spreafico, Li Tong, Shao Hui Huang, John N Waldron

  • March 12, 2026

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