Inner retinal layer thickness reflects plasma biomarkers in preclinical Alzheimer’s disease - Takeaways - MDSpire
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Retinal Layer Thickness Correlates with Plasma Biomarkers in Individuals at Risk for Alzheimer’s Disease

  • By

  • Jane W. Chan

  • Ziyuan Wang

  • Emily Xu

  • Ibrahim Abboud

  • Aya Alhasany

  • Sophia Xu

  • Xiaomeng Wu

  • Natalie Astraea

  • Fei Jiang

  • Zhihong Jewel Hu

  • May 18, 2026

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  • 1

    This pilot study explores the correlation between retinal layer thickness and plasma biomarkers in cognitively normal adults at risk for Alzheimer's disease.

  • 2

    Thinner inner nuclear layer (INL) and ganglion cell layer (GCL) measurements are associated with higher levels of p-tau217 and GFAP.

  • 3

    Spectral-domain optical coherence tomography (SD-OCT) provides non-invasive, layer-specific retinal measurements relevant to Alzheimer's disease.

  • 4

    The study emphasizes the need for larger, longitudinal studies to validate preliminary findings on retinal thickness and plasma biomarkers.

  • 5

    Current plasma biomarkers, while valuable, may not fully capture the early changes detectable through retinal imaging in Alzheimer's disease.

Original Source(s)

Inner retinal layer thickness reflects plasma biomarkers in preclinical Alzheimer’s disease

  • by Jane W. Chan, Ziyuan Wang, Emily Xu, Ibrahim Abboud, Aya Alhasany, Sophia Xu, Xiaomeng Wu, Natalie Astraea, Fei Jiang, Zhihong Jewel Hu

  • May 18, 2026

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