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1
The study involved 100 participants, including 58 with coronary heart disease (CHD) and 42 controls, to assess biomarker associations with CHD severity.
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2
Serum levels of homocysteine (Hcy), uric acid (UA), and high-density lipoprotein cholesterol (HDL-C) were significantly altered in CHD patients compared to controls.
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3
Gensini scores positively correlated with Hcy and UA, while negatively correlating with HDL-C, indicating their relationship with coronary stenosis severity.
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4
The combined detection of Hcy, UA, and HDL-C improved the explained variance of the Gensini score from 31% to 48%, enhancing diagnostic accuracy.
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5
The study concluded that Hcy, UA, and HDL-C are significant biomarkers for assessing CHD severity and may aid in early detection of coronary stenosis.
