Case Study: Concurrent Colorectal Adenocarcinomas Exhibiting Divergent Mismatch Repair Status: Insights into Lynch-like Syndrome and Serrated Pathway Correlation - Takeaways - MDSpire

Case Study: Concurrent Colorectal Adenocarcinomas Exhibiting Divergent Mismatch Repair Status: Insights into Lynch-like Syndrome and Serrated Pathway Correlation

  • By

  • Daming Chen

  • Jiansheng Zhang

  • Jinchao Bi

  • Zhiyue Bai

  • Lei Zhang

  • Jingzhen Bai

  • April 27, 2026

  • 0 min

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  • 1

    This case report highlights synchronous colorectal adenocarcinomas with divergent mismatch repair status, presenting unique clinical challenges.

  • 2

    The patient, a 67-year-old female, was diagnosed with poorly differentiated dMMR adenocarcinoma in the ascending colon and pMMR adenocarcinoma in the rectum.

  • 3

    Molecular analyses revealed no pathogenic MMR gene variants, supporting a diagnosis of Lynch-like syndrome in the context of synchronous cancers.

  • 4

    Regional lymph node MMR phenotyping indicated higher metastatic potential for the rectal lesion, guiding adjuvant treatment decisions.

  • 5

    The study emphasizes the importance of lesion-specific molecular profiling for individualized therapy in patients with synchronous colorectal cancers.

Original Source(s)

Case Study: Concurrent Colorectal Adenocarcinomas Exhibiting Divergent Mismatch Repair Status: Insights into Lynch-like Syndrome and Serrated Pathway Correlation

  • by Daming Chen, Jiansheng Zhang, Jinchao Bi, Zhiyue Bai, Lei Zhang, Jingzhen Bai

  • April 27, 2026

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