The impact of estrogen status on the gut microbiome: a systematic review and meta-analysis - Takeaways - MDSpire

The impact of estrogen status on the gut microbiome: a systematic review and meta-analysis

  • By

  • Kristina Saravinovska

  • Daniele Santi

  • Francesco Costantino

  • Alessandro Prete

  • Antoan Stefan Šojat

  • Giorgia Spaggiari

  • Miomira Ivović

  • Irene Lambrinoudaki

  • Eleni Armeni

  • Aleksandar Jurišić

  • Sladjana Mihajlović

  • Svetlana Vujović

  • Ljiljana V. Marina

  • April 2, 2026

  • 0 min

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  • 1

    Estrogens may influence gut microbiome composition, but evidence from studies comparing hypoestrogenic and euestrogenic women is inconsistent.

  • 2

    This meta-analysis included 7 studies with a total of 1,790 women, focusing on α-diversity and bacterial phyla abundances.

  • 3

    No significant differences were found in α-diversity or the abundances of Bacteroidetes and Firmicutes between hypoestrogenic and euestrogenic women.

  • 4

    High study heterogeneity and variability in methodological quality limit the interpretation of findings regarding estrogen's impact on gut microbiome.

  • 5

    Further high-quality, well-controlled studies are necessary to clarify the relationship between estrogen status and gut microbiome alterations.

Original Source(s)

The impact of estrogen status on the gut microbiome: a systematic review and meta-analysis

  • by Kristina Saravinovska, Daniele Santi, Francesco Costantino, Alessandro Prete, Antoan Stefan Šojat, Giorgia Spaggiari, Miomira Ivović, Irene Lambrinoudaki, Eleni Armeni, Aleksandar Jurišić, Sladjana Mihajlović, Svetlana Vujović, Ljiljana V. Marina

  • April 2, 2026

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