Lateralized glymphatic system impairment in acute ischemic stroke: a DTI–ALPS study of upper limb motor function - Takeaways - MDSpire

Lateralized glymphatic system impairment in acute ischemic stroke: a DTI–ALPS study of upper limb motor function

  • By

  • Zilong Zhu

  • Zhilong Zhao

  • Lihua Zhou

  • Junfeng Xiong

  • Tianrui Zhang

  • Chunling Wei

  • Jianbin Zhang

  • May 28, 2026

  • 0 min

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  • 1

    The glymphatic system (GS) is crucial for brain waste clearance and maintaining cerebral homeostasis, particularly during acute ischemic stroke (AIS).

  • 2

    In a study of 69 AIS patients and 34 healthy controls, DTI-ALPS revealed significant GS impairment in both left- and right-sided infarction groups compared to controls.

  • 3

    Left hemisphere DTI-ALPS indices were negatively correlated with NIHSS scores and positively correlated with FMA-UE scores in the left infarction group.

  • 4

    The study found that GS impairment patterns in AIS are independent of infarct laterality, suggesting a left-dominant pattern in right-handed individuals.

  • 5

    The left hemisphere DTI-ALPS index may serve as a promising biomarker for assessing upper limb motor function in the acute phase of stroke.

Original Source(s)

Lateralized glymphatic system impairment in acute ischemic stroke: a DTI–ALPS study of upper limb motor function

  • by Zilong Zhu, Zhilong Zhao, Lihua Zhou, Junfeng Xiong, Tianrui Zhang, Chunling Wei, Jianbin Zhang

  • May 28, 2026

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