Comparison of Dexmedetomidine and Midazolam-Fentanyl for Sedation and Analgesia During Surgery: A Systematic Review and Meta-Analysis - Takeaways - MDSpire

Comparison of Dexmedetomidine and Midazolam-Fentanyl for Sedation and Analgesia During Surgery: A Systematic Review and Meta-Analysis

  • By

  • Hashim Talib Hashim

  • Mostafa A. Khalifa

  • Aya Ahmed Shimal

  • Marafi Jammaa Ahmed

  • Mohamed H. Elbadawi

  • Khadeeja Ali Hamzah

  • Abdulhadi M. A. Mahgoub

  • Alaa R. AL-Ihribat

  • Salem Waleed Salem Mohamed

  • Fathima Raahima Riyas Mohamed

  • Elian Khalafalla

  • Amna Kamil

  • Anzah Imtiaz Wagga

  • Ahmed Mohamed Shahin

  • Abdelrhman H. Mohammed

  • March 27, 2026

  • 0 min

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  • 1

    This meta-analysis compares dexmedetomidine and midazolam-fentanyl for sedation and analgesia in surgical patients.

  • 2

    Dexmedetomidine significantly reduced mean arterial pressure and heart rates compared to midazolam-fentanyl.

  • 3

    Respiratory rate and oxygen saturation showed no significant differences between dexmedetomidine and midazolam-fentanyl.

  • 4

    Adverse events were comparable between the two sedation methods, indicating similar safety profiles.

  • 5

    Further research is needed to evaluate long-term outcomes such as postoperative delirium and residual sedation.

Original Source(s)

Comparison of Dexmedetomidine and Midazolam-Fentanyl for Sedation and Analgesia During Surgery: A Systematic Review and Meta-Analysis

  • by Hashim Talib Hashim, Mostafa A. Khalifa, Aya Ahmed Shimal, Marafi Jammaa Ahmed, Mohamed H. Elbadawi, Khadeeja Ali Hamzah, Abdulhadi M. A. Mahgoub, Alaa R. AL-Ihribat, Salem Waleed Salem Mohamed, Fathima Raahima Riyas Mohamed, Elian Khalafalla, Amna Kamil, Anzah Imtiaz Wagga, Ahmed Mohamed Shahin, Abdelrhman H. Mohammed

  • March 27, 2026

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