Multiple sclerosis patients under treatment with interferon β1-a or ocrelizumab exhibit different T and B cell responses to SARS-CoV-2 vaccine - Takeaways - MDSpire

Multiple sclerosis patients under treatment with interferon β1-a or ocrelizumab exhibit different T and B cell responses to SARS-CoV-2 vaccine

  • By

  • Antonietta Liotti

  • Giorgia Teresa Maniscalco

  • Anne Lise Ferrara

  • Valeria Mazzone

  • Maedeh Dehbozorgi

  • Annamária Szabó

  • Martina Belardo

  • Daria Marcogiuseppe

  • Antonio De Martino

  • Maria Elena Di Battista

  • Giovanna Servillo

  • Ornella Moreggia

  • Daniele Di Giulio Cesare

  • Vincenzo Andreone

  • Gilda Varricchi

  • Veronica De Rosa

  • June 16, 2026

  • 0 min

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  • 1

    This study evaluated T and B cell responses to SARS-CoV-2 vaccination in multiple sclerosis patients treated with interferon β1-a or ocrelizumab.

  • 2

    CD20+ B-cells were significantly decreased in ocrelizumab-treated patients compared to those treated with interferon β1-a before and after vaccination.

  • 3

    Both treatment groups exhibited comparable CD8+ and CD4+ T cell responses, indicating a robust vaccine-induced immune response.

  • 4

    Th17 cells increased post-vaccination only in the ocrelizumab-treated group, suggesting distinct immunological profiles between treatments.

  • 5

    The study highlights the need to understand the immunosuppressive effects of disease-modifying therapies on vaccine responses in multiple sclerosis patients.

Original Source(s)

Multiple sclerosis patients under treatment with interferon β1-a or ocrelizumab exhibit different T and B cell responses to SARS-CoV-2 vaccine

  • by Antonietta Liotti, Giorgia Teresa Maniscalco, Anne Lise Ferrara, Valeria Mazzone, Maedeh Dehbozorgi, Annamária Szabó, Martina Belardo, Daria Marcogiuseppe, Antonio De Martino, Maria Elena Di Battista, Giovanna Servillo, Ornella Moreggia, Daniele Di Giulio Cesare, Vincenzo Andreone, Gilda Varricchi, Veronica De Rosa

  • June 16, 2026

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