Raman Spectroscopy Moves to the Front Line of Pandemic Preparedness

Comprehensive review highlights label-free viral detection – and the hurdles to real-world deployment

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Raman spectroscopy offers rapid, label-free insights into viruses and host responses, enhancing pandemic preparedness.
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Enhanced Raman techniques like SERS, TERS, and CARS improve sensitivity and resolution for detecting viral particles.
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Raman-based methods have shown rapid detection capabilities for influenza and high accuracy for SARS-CoV-2 in saliva.
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Research focus is skewed towards accessible viruses, leaving high-risk pathogens like Lassa and Marburg underexplored.
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Technical barriers such as weak signal intensity and fluorescence interference hinder the clinical translation of Raman methods.

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