T helper 17 cells and group 3 innate lymphoid cells define a spectrum of psoriasis endotypes - Takeaways - MDSpire

T helper 17 cells and group 3 innate lymphoid cells define a spectrum of psoriasis endotypes

  • By

  • Michael P. Schön

  • July 2, 2026

  • 0 min

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  • 1

    Psoriasis involves the IL-23/IL-17 axis, driven by Th17 cells and ILC3s, which produce cytokines that activate keratinocytes and sustain inflammation.

  • 2

    Th17 cells are adaptive immune cells that maintain chronic inflammation, while ILC3s provide a rapid, innate source of IL-17 and IL-22.

  • 3

    Crosstalk between Th17 cells and ILC3s creates a self-amplifying inflammatory loop in psoriatic lesions.

  • 4

    Immunological tipping points, such as the transition from innate to adaptive immunity, regulate the balance between Th17 cells and ILC3s.

  • 5

    ILC3s and Th17 cells compete for IL-2, influencing the differentiation of Tregs and the inflammatory response in psoriasis.

Original Source(s)

T helper 17 cells and group 3 innate lymphoid cells define a spectrum of psoriasis endotypes

  • by Michael P. Schön

  • July 2, 2026

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