Comparison of anti-human T cell globulins on immune reconstitution and early infections after autologous transplant in patients with multiple sclerosis

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Autologous hematopoietic stem cell transplantation (AHSCT) is effective for treatment-resistant multiple sclerosis (MS) patients.
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The study compares the effects of anti-thymocyte globulin (ATG) and anti-T-lymphocyte globulin (ATLG) on immune reconstitution post-AHSCT.
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Sixty-three MS patients underwent AHSCT, receiving either ATG or ATLG as part of their conditioning regimen.
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Faster immune reconstitution was observed at day 30 in patients receiving pre-transplant ATLG compared to post-transplant ATG.
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The study aims to provide comparative data to support standardized lymphodepleting regimens for AHSCT in MS patients.

Bone Marrow Transplantation

by Johanna Richter, Nico Gagelmann, Felix Fischbach, Kristin Rathje, Lena Kristina Pfeffer, Boris Fehse, Anita Badbaran, Susanna Carolina Berger, Rolf Krause, Evgeny Klyuchnikov, Christine Wolschke, Catherina Lueck, Francis Ayuk, Manuel A. Friese, Christoph Heesen, Nicolaus Kröger
November 27, 2025

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