Clinical Image: Extensive Calcification of Subcutaneous Tissue in Overlap Syndrome of SLE and SSc

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A 50-year-old female with systemic lupus erythematosus and systemic sclerosis presented with advancing subcutaneous lesions.
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The patient developed multiple symmetric subcutaneous indurations and large, plate-like calcified plaques over five years.
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Imaging studies confirmed extensive subcutaneous calcinosis, with lesions being nontender but prone to rupture.
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Mycophenolate mofetil was escalated to manage the chronic inflammatory process due to the severity of the lesions.
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No guideline-endorsed therapies exist for this condition, highlighting the need for effective management of the autoimmune disorder.

Acr Open Rheumatology

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