Clinical Image: Extensive subcutaneous calcification in SLE/SSc overlap syndrome - Takeaways - MDSpire
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Clinical Image: Extensive Calcification of Subcutaneous Tissue in Overlap Syndrome of SLE and SSc

  • By

  • Jianmei Cao

  • Jinchao Jia

  • July 1, 2026

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  • 1

    A 50-year-old female with systemic lupus erythematosus and systemic sclerosis presented with advancing subcutaneous lesions.

  • 2

    The patient developed multiple symmetric subcutaneous indurations and large, plate-like calcified plaques over five years.

  • 3

    Imaging studies confirmed extensive subcutaneous calcinosis, with lesions being nontender but prone to rupture.

  • 4

    Mycophenolate mofetil was escalated to manage the chronic inflammatory process due to the severity of the lesions.

  • 5

    No guideline-endorsed therapies exist for this condition, highlighting the need for effective management of the autoimmune disorder.

Original Source(s)

Clinical Image: Extensive subcutaneous calcification in SLE/SSc overlap syndrome

  • by Jianmei Cao, Jinchao Jia

  • July 1, 2026

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