Case Report: Giant cell reparative granuloma of the humerus and femur—two rare cases with atypical skeletal involvement

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Giant cell reparative granuloma (GCRG) is a rare benign lesion primarily found in the mandible and maxilla, with long bone involvement being extremely uncommon.
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The report details two cases of GCRG in the proximal humerus and distal femur, both associated with prior mechanical strain or trauma.
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Imaging studies initially suggested giant cell tumors of bone, but postoperative histopathological examination confirmed the diagnosis of GCRG.
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Accurate diagnosis of GCRG relies on integrating radiologic and histopathological findings to avoid misdiagnosis and ensure proper management.
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These cases highlight the need to consider GCRG in the differential diagnosis of osteolytic lesions at atypical skeletal sites, especially post-trauma.

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