Cognitive Impairment and Secondary Narcolepsy Associated with Craniopharyngioma: A Case Report - Takeaways - MDSpire

Cognitive Impairment and Secondary Narcolepsy Associated with Craniopharyngioma: A Case Report

  • By

  • Amelia Nur Vidyanti

  • Atika Rahmadini

  • Rifki Habibi Rahman

  • Astuti Prodjohardjono

  • Desin Pambudi Sejahtera

  • Muhammad Hardhantyo

  • January 15, 2026

  • 0 min

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  • 1

    Craniopharyngiomas can impair hypothalamic function, leading to neuroendocrine disturbances and sleep disorders like hypersomnia and narcolepsy.

  • 2

    Secondary narcolepsy, unlike primary narcolepsy, often lacks clear genetic markers, complicating diagnosis and treatment.

  • 3

    The case report details a 19-year-old woman with excessive daytime sleepiness and cognitive deficits following craniopharyngioma treatment.

  • 4

    Polysomnography confirmed narcolepsy with short sleep latency and REM sleep predominance, despite the absence of cataplexy.

  • 5

    The patient showed significant improvement in sleep and cognitive function after tailored pharmacologic and behavioral interventions.

Original Source(s)

Cognitive Impairment and Secondary Narcolepsy Associated with Craniopharyngioma: A Case Report

  • by Amelia Nur Vidyanti, Atika Rahmadini, Rifki Habibi Rahman, Astuti Prodjohardjono, Desin Pambudi Sejahtera, Muhammad Hardhantyo

  • January 15, 2026

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