Multiple ground-glass nodules after lobectomy for multiple primary lung cancer: a case report - Takeaways - MDSpire

Multiple ground-glass nodules after lobectomy for multiple primary lung cancer: a case report

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A 74-year-old female with no smoking history developed synchronous and metachronous multiple primary lung cancer (MPLC) with ground-glass nodules (GGNs).
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Postoperative pathology confirmed synchronous MPLC, and genetic testing identified an EGFR L858R mutation in the patient.
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In April 2022, follow-up CT scans revealed new GGNs in the left lower lobe, which progressed over time.
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Bronchoscopic biopsy in 2024 confirmed minimally invasive adenocarcinoma, indicating metachronous MPLC.
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EGFR-TKI targeted therapy was initiated, leading to gradual shrinkage and complete remission of the GGNs.

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