Baseline working memory was associated with improvement in psychological quality of life in patients with persistent depressive symptoms: a prospective observational study - Takeaways - MDSpire

Baseline working memory was associated with improvement in psychological quality of life in patients with persistent depressive symptoms: a prospective observational study

  • By

  • Yuki Oe

  • Mariko Kurihara

  • Tomonari Hayasaka

  • Izumi Nagashima

  • Masami Murao

  • Yasuyuki Matsumoto

  • Yoshikazu Takaesu

  • Takashi Tsuboi

  • Koichiro Watanabe

  • Hitoshi Sakurai

  • May 21, 2026

  • 0 min

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  • 1

    Cognitive dysfunction significantly affects quality of life and functional outcomes in patients with persistent depressive symptoms.

  • 2

    Higher baseline working memory is linked to greater improvement in psychological quality of life over six months.

  • 3

    No significant overall improvement in quality of life or functioning was observed in the study cohort over six months.

  • 4

    The study included 84 patients with persistent depressive symptoms, assessing cognitive function and quality of life at multiple time points.

  • 5

    Findings suggest working memory may serve as a prognostic marker for psychological well-being in patients with persistent depressive symptoms.

Original Source(s)

Baseline working memory was associated with improvement in psychological quality of life in patients with persistent depressive symptoms: a prospective observational study

  • by Yuki Oe, Mariko Kurihara, Tomonari Hayasaka, Izumi Nagashima, Masami Murao, Yasuyuki Matsumoto, Yoshikazu Takaesu, Takashi Tsuboi, Koichiro Watanabe, Hitoshi Sakurai

  • May 21, 2026

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