Scientists Extract Genomes from 1930s Tumors
A modified ancient DNA workflow reveals genetic and microbial clues hidden in decades-old FFPE blocks
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Researchers at the University of Chicago have developed methods to extract usable genetic information from 90-year-old medical specimens.
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The study focuses on colorectal cancer samples collected between 1932 and 2023, highlighting rising incidence in younger adults.
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The team optimized DNA extraction techniques to preserve fragmented DNA, enabling reconstruction and alignment to the human genome.
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In addition to tumor DNA, microbial DNA was analyzed, revealing shifts in gut bacteria linked to colorectal cancer over decades.
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The approach may allow for historical analysis of disease evolution and could be applied to other archived specimens beyond colorectal cancer.
