Primary endoscopic nasopharyngectomy for nasopharyngeal carcinoma: systematic review & meta-analysis - Takeaways - MDSpire

Primary endoscopic nasopharyngectomy for nasopharyngeal carcinoma: systematic review & meta-analysis

  • By

  • Siyuan Ding

  • Leo Li

  • Jenny Lee

  • Brian Mak

  • Christopher Liao

  • Andy Chan

  • Levina Li

  • Calvin Lai

  • Samuel Chow

  • Jason Chan

  • David Yeung

  • June 26, 2026

  • 0 min

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  • 1

    A systematic review and meta-analysis evaluated primary endoscopic nasopharyngectomy (pENPG) for treating primary nasopharyngeal carcinoma (pNPC).

  • 2

    Four studies involving 164 patients were included, with two studies analyzing pENPG alone and two comparing it to intensity-modulated radiotherapy (IMRT).

  • 3

    The pooled 5-year overall survival (OS) for pENPG was 90.6%, with 100% OS for stage I NPC in two studies. IMRT showed a 5-year OS of 99.1% for stage I disease.

  • 4

    Radiotherapy-associated toxicities were significantly reduced with pENPG compared to IMRT, highlighting its potential benefits for early-stage disease.

  • 5

    The use of pENPG is rare, and further prospective studies are necessary to evaluate its feasibility as an alternative to IMRT for early-stage NPC.

Original Source(s)

Primary endoscopic nasopharyngectomy for nasopharyngeal carcinoma: systematic review & meta-analysis

  • by Siyuan Ding, Leo Li, Jenny Lee, Brian Mak, Christopher Liao, Andy Chan, Levina Li, Calvin Lai, Samuel Chow, Jason Chan, David Yeung

  • June 26, 2026

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