Editorial: Neutrophil function and dysfunction: pathways, impact, and therapeutic insights - Takeaways - MDSpire

Editorial: Neutrophil function and dysfunction: pathways, impact, and therapeutic insights

  • By

  • Baochen Fang

  • Mengjie Li

  • Yiwei Zhu

  • Alan Y. Hsu

  • Lihui Guo

  • Zhifeng Chen

  • Minhao Liu

  • Hui Yu

  • Hongli Xu

  • Zhicheng Peng

  • Hui Chen

  • June 15, 2026

  • 0 min

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  • 1

    Neutrophils are essential for host defense but can cause tissue injury when dysregulated, contributing to various diseases.

  • 2

    Aberrant degranulation and altered granule homeostasis in neutrophils lead to systemic inflammation and tissue damage.

  • 3

    Neutrophil heterogeneity plays a significant role in disease pathology and may provide diagnostic and prognostic insights.

  • 4

    Neutrophils are being explored as therapeutic targets in cancer, influencing tumor microenvironments and anti-tumor immunity.

  • 5

    Emerging research highlights the need for precise regulation of neutrophil functions to balance immune defense and tissue preservation.

Original Source(s)

Editorial: Neutrophil function and dysfunction: pathways, impact, and therapeutic insights

  • by Baochen Fang, Mengjie Li, Yiwei Zhu, Alan Y. Hsu, Lihui Guo, Zhifeng Chen, Minhao Liu, Hui Yu, Hongli Xu, Zhicheng Peng, Hui Chen

  • June 15, 2026

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