An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on physical and psychological wellbeing in women experiencing menopausal symptoms: a randomised, double-blind, placebo-controlled trial - Takeaways - MDSpire

An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on physical and psychological wellbeing in women experiencing menopausal symptoms: a randomised, double-blind, placebo-controlled trial

  • By

  • Adrian L. Lopresti

  • Stephen J. Smith

  • Frederick R. Ferdinands

  • June 2, 2026

  • 0 min

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  • 1

    Khapregesic®, derived from Khaya senegalensis, was tested for safety and efficacy in alleviating menopausal symptoms in women.

  • 2

    The study involved 140 peri- and postmenopausal women, who received either Khapregesic® or a placebo for 28 days.

  • 3

    No significant differences were found in primary and secondary outcomes across the full cohort of participants.

  • 4

    Postmenopausal women showed significant improvements in psychological symptoms, fatigue, and sleep disturbances with Khapregesic®.

  • 5

    Khapregesic® was generally well tolerated, with mild gastrointestinal symptoms reported as transient.

Original Source(s)

An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on physical and psychological wellbeing in women experiencing menopausal symptoms: a randomised, double-blind, placebo-controlled trial

  • by Adrian L. Lopresti, Stephen J. Smith, Frederick R. Ferdinands

  • June 2, 2026

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