Association between serum progesterone levels on the day of embryo transfer and clinical pregnancy outcomes in POSEIDON Group 1 patients - Takeaways - MDSpire

Association between serum progesterone levels on the day of embryo transfer and clinical pregnancy outcomes in POSEIDON Group 1 patients

  • By

  • Xin Wang

  • Lili Zhuang

  • Luqing Zhang

  • Zhenteng Liu

  • Huishan Zhao

  • Dongmei Zhao

  • Yingqian Peng

  • Hongchu Bao

  • May 28, 2026

  • 0 min

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  • 1

    The study investigated the relationship between serum progesterone levels on the day of embryo transfer and clinical pregnancy outcomes in POSEIDON Group 1 patients.

  • 2

    A total of 402 patients undergoing single or double embryo transfer were enrolled in this retrospective cohort study conducted from January 2016 to December 2023.

  • 3

    The clinical pregnancy rate was highest in the serum progesterone range of 9.45-23.32 ng/mL and decreased significantly when levels exceeded 23.32 ng/mL.

  • 4

    High serum progesterone levels (≥23.32 ng/mL) were independently associated with a lower clinical pregnancy rate after adjusting for confounders.

  • 5

    BMI significantly modified the association between serum progesterone and clinical pregnancy rate, affecting normal-weight but not overweight/obese patients.

Original Source(s)

Association between serum progesterone levels on the day of embryo transfer and clinical pregnancy outcomes in POSEIDON Group 1 patients

  • by Xin Wang, Lili Zhuang, Luqing Zhang, Zhenteng Liu, Huishan Zhao, Dongmei Zhao, Yingqian Peng, Hongchu Bao

  • May 28, 2026

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