Nomogram-based prediction of hemorrhagic transformation risk integrating platelet-to-white blood cell ratio in patients with acute ischemic stroke after intravenous thrombolysis - Takeaways - MDSpire

Nomogram-based prediction of hemorrhagic transformation risk integrating platelet-to-white blood cell ratio in patients with acute ischemic stroke after intravenous thrombolysis

  • By

  • Qi Sun

  • Jiahao Chen

  • June 17, 2026

  • 0 min

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  • 1

    Hemorrhagic transformation (HT) is a significant complication in acute ischemic stroke (AIS) patients after intravenous thrombolysis (IVT).

  • 2

    Lower platelet-to-white blood cell ratio (PWR) is independently associated with increased risk and severity of HT following IVT in AIS patients.

  • 3

    The study included 790 AIS patients treated with IVT, revealing that those with HT had significantly lower PWR levels.

  • 4

    Patients in the highest PWR quartile had a 67% reduced risk of HT, as shown by multivariable logistic regression analysis.

  • 5

    A nomogram model integrating PWR and other risk factors achieved an AUC of 0.767 for predicting HT risk in AIS patients.

Original Source(s)

Nomogram-based prediction of hemorrhagic transformation risk integrating platelet-to-white blood cell ratio in patients with acute ischemic stroke after intravenous thrombolysis

  • by Qi Sun, Jiahao Chen

  • June 17, 2026

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