Analysis of the association between the neutrophil-to-lymphocyte ratio (NLR) and liver injury complicating acute pancreatitis: a retrospective study - Takeaways - MDSpire

Exploring the Relationship Between Neutrophil-to-Lymphocyte Ratio (NLR) and Acute Liver Injury in Acute Pancreatitis: A Retrospective Analysis

  • By

  • Jinbao Li

  • Xueling Liu

  • Rongzhen Zhao

  • Haoran Zhu

  • Juan Wu

  • Weijian Huang

  • Bo Li

  • Qinghua Wang

  • July 21, 2026

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  • 1

    Acute liver injury (ALI) occurs in 37.7% of patients with acute pancreatitis, exacerbating systemic inflammation and increasing mortality.

  • 2

    Each one-unit increase in the neutrophil-to-lymphocyte ratio (NLR) raises the risk of ALI by 11%, with a significant threshold identified at NLR = 2.92.

  • 3

    Patients in the highest NLR quartile have a 5.42-fold higher risk of developing ALI compared to those in the lowest quartile.

  • 4

    NLR alone predicts ALI with an area under the curve (AUC) of 0.688, while combining NLR with CRP and gallstones improves AUC to 0.756.

  • 5

    The study suggests that NLR can serve as an early warning signal for liver injury in acute pancreatitis, aiding in clinical decision-making.

Original Source(s)

Analysis of the association between the neutrophil-to-lymphocyte ratio (NLR) and liver injury complicating acute pancreatitis: a retrospective study

  • by Jinbao Li, Xueling Liu, Rongzhen Zhao, Haoran Zhu, Juan Wu, Weijian Huang, Bo Li, Qinghua Wang

  • July 21, 2026

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