Efficacy and safety of ozone autohemotherapy for zoster-associated pain: a meta-analysis and trial sequential analysis - Takeaways - MDSpire

Efficacy and safety of ozone autohemotherapy for zoster-associated pain: a meta-analysis and trial sequential analysis

  • By

  • Chunmei Wu

  • Zehao Liu

  • Yixin Zhang

  • Yangyang Li

  • Funing Liu

  • Yong Chen

  • Xiaojuan Liu

  • An Yang

  • Huide Wang

  • Qing Zhong

  • June 3, 2026

  • 0 min

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  • 1

    The study systematically evaluates the efficacy and safety of ozone autohemotherapy (O₃-AHT) for treating zoster-associated pain (ZAP).

  • 2

    A total of 20 studies involving 1,519 patients were included, revealing significant improvements in pain scores and quality of life with O₃-AHT compared to controls.

  • 3

    O₃-AHT significantly decreased inflammatory factor levels and improved effective pain relief rates, with no significant difference in adverse reactions between groups.

  • 4

    Trial sequential analysis indicated that the cumulative sample size exceeded the required information size for the primary outcome, supporting the reliability of the findings.

  • 5

    The quality of evidence was rated as very low to moderate, primarily due to risks of bias and heterogeneity among the included studies.

Original Source(s)

Efficacy and safety of ozone autohemotherapy for zoster-associated pain: a meta-analysis and trial sequential analysis

  • by Chunmei Wu, Zehao Liu, Yixin Zhang, Yangyang Li, Funing Liu, Yong Chen, Xiaojuan Liu, An Yang, Huide Wang, Qing Zhong

  • June 3, 2026

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