Coronary microvascular function in patients with sepsis and myocardial injury: an invasive coronary physiology study - Takeaways - MDSpire
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Assessment of Coronary Microvascular Function in Sepsis Patients with Myocardial Injury: Insights from an Invasive Coronary Physiology Investigation

  • By

  • Samantha Lörstad

  • Per Åstrand

  • Patrik Gille-Johnson

  • Yunzhang Wang

  • Christina Ekenbäck

  • Fadi Jokhaji

  • Felix Böhm

  • Patrik Hjalmarsson

  • Shajan Shekarestan

  • Tomas Jernberg

  • Sara Tehrani

  • Kambiz Shahgaldi

  • Jonas Persson

  • July 2, 2026

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  • 1

    Myocardial injury is prevalent in sepsis and linked to adverse outcomes, with coronary microvascular dysfunction proposed as a contributing factor.

  • 2

    The study aimed to assess coronary microvascular function in sepsis patients with myocardial injury using invasive thermodilution-based methods.

  • 3

    Patients were enrolled based on elevated plasma hs-cTnT concentrations, meeting Sepsis-3 criteria, and were screened for eligibility.

  • 4

    Coronary angiography was performed to evaluate obstructive coronary artery disease and assess coronary microvascular function in sepsis patients.

  • 5

    The study was ethically approved, conducted in accordance with the Declaration of Helsinki, and all participants provided informed consent.

Original Source(s)

Coronary microvascular function in patients with sepsis and myocardial injury: an invasive coronary physiology study

  • by Samantha Lörstad, Per Åstrand, Patrik Gille-Johnson, Yunzhang Wang, Christina Ekenbäck, Fadi Jokhaji, Felix Böhm, Patrik Hjalmarsson, Shajan Shekarestan, Tomas Jernberg, Sara Tehrani, Kambiz Shahgaldi, Jonas Persson

  • July 2, 2026

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