Editorial: The role of circular RNAs and MicroRNAs in non-small cell lung cancer: from mechanisms to therapeutic potential - Takeaways - MDSpire

Editorial: The role of circular RNAs and MicroRNAs in non-small cell lung cancer: from mechanisms to therapeutic potential

  • By

  • Alexandru Tirpe

  • Paola Campomenosi

  • Ioana Berindan-Neagoe

  • May 27, 2026

  • 0 min

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  • 1

    Lung cancer is the leading malignancy globally, with 2.48 million new cases and 1.81 million deaths reported in 2022.

  • 2

    Non-coding RNAs play significant roles in oncogenic processes, including EMT, invasion, and therapy resistance in non-small cell lung cancer.

  • 3

    CircUBE2G1 is upregulated in lung adenocarcinoma and promotes lymph node metastasis, highlighting its potential as a therapeutic target.

  • 4

    Circ_0001859 is associated with NSCLC progression and metastasis through the circ_0001859/miR-101-3p/MMP1 regulatory axis.

  • 5

    MicroRNAs miR-17-5p and miR-20a-5p exhibit context-dependent prognostic roles in NSCLC, influencing invasion and migration.

Original Source(s)

Editorial: The role of circular RNAs and MicroRNAs in non-small cell lung cancer: from mechanisms to therapeutic potential

  • by Alexandru Tirpe, Paola Campomenosi, Ioana Berindan-Neagoe

  • May 27, 2026

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