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Tricuspid regurgitation thresholds reassessed

The proposed framework classified 30% of patients as high or extreme risk, compared with 12% classified as having severe or greater tricuspid regurgitation under established grading schemes.

  • By

  • Kathryn Wighton

  • September 9, 2026

  • 4 min

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  • 1

    A study published in JAMA Cardiology assessed tricuspid regurgitation thresholds in patients with transthyretin amyloid cardiomyopathy.

  • 2

    The study included 1,124 patients, with a median age of 80 years, and excluded those with prior tricuspid valve interventions.

  • 3

    New disease-specific echocardiographic thresholds for tricuspid regurgitation showed better prognostic discrimination than existing guidelines.

  • 4

    The proposed thresholds for tricuspid regurgitation were significantly lower than conventional cutoffs in current guidelines.

  • 5

    The framework demonstrated greater discrimination for mortality and heart failure hospitalization compared to existing guideline definitions.

Original Source(s)

Tricuspid regurgitation thresholds reassessed

  • by Kathryn Wighton

  • September 9, 2026

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