Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases - Takeaways - MDSpire

Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases

  • By

  • Sophia Navarre

  • Maki N. Ishibashi

  • Achuth Nair

  • Ivan Reyes-Torres

  • Meriem Belabed

  • Laszlo Halasz

  • Matthew D. Park

  • Raphaël Mattiuz

  • Merouane Ounadjela

  • Gertrude Gunset

  • Jorge Mansilla-Soto

  • Judith Feucht

  • Annalisa Cabriolu

  • Jessica Le Berichel

  • Alexander Birbrair

  • Justin Eyquem

  • Brian D. Brown

  • Miriam Merad

  • Michel Sadelain

  • Jalal Ahmed

  • May 22, 2026

  • 0 min

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  • 1

    Irradiation of tumors enhances the effectiveness of CAR T cells by sensitizing target cells to cytotoxicity and improving T cell persistence.

  • 2

    The study utilized a syngeneic lung tumor model to assess CAR T cell interactions within the tumor microenvironment.

  • 3

    Irradiated tumors showed significantly reduced tumor burden and increased survival in mice treated with CAR T cells.

  • 4

    Irradiation did not affect CAR T cell homing but resulted in higher numbers of CAR T cells in irradiated tumor sites over time.

  • 5

    The findings suggest that combining tumor irradiation with CAR T cell therapy may widen the therapeutic window for treating solid tumors.

Original Source(s)

Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases

  • by Sophia Navarre, Maki N. Ishibashi, Achuth Nair, Ivan Reyes-Torres, Meriem Belabed, Laszlo Halasz, Matthew D. Park, Raphaël Mattiuz, Merouane Ounadjela, Gertrude Gunset, Jorge Mansilla-Soto, Judith Feucht, Annalisa Cabriolu, Jessica Le Berichel, Alexander Birbrair, Justin Eyquem, Brian D. Brown, Miriam Merad, Michel Sadelain, Jalal Ahmed

  • May 22, 2026

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