Pulse pressure and cardiometabolic disease progression: associations with incident multimorbidity and mortality in UK biobank - Takeaways - MDSpire
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The Relationship Between Pulse Pressure and the Advancement of Cardiometabolic Diseases: Links to New Multimorbidity and Mortality in the UK Biobank Study

  • By

  • Ting Lin

  • Shuai Hu

  • Wen Gong

  • Linqi Li

  • Zhaowei Zhu

  • Hebin Xie

  • Feijun Zhao

  • June 23, 2026

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  • 1

    The study analyzed 403,851 UK Biobank participants to assess the relationship between pulse pressure and cardiometabolic diseases.

  • 2

    A 1-SD increase in pulse pressure was linked to a 13% higher risk of developing cardiometabolic diseases and an 18% higher risk of cardiometabolic multimorbidity.

  • 3

    The strongest association between pulse pressure and cardiometabolic multimorbidity was observed in participants with stroke, showing a 23% increased risk.

  • 4

    Subgroup analyses indicated that the pulse pressure-cardiometabolic multimorbidity association was most pronounced in individuals under 60 years and those with a BMI of 18.5 to 25 kg/m2.

  • 5

    Threshold-effect analyses identified specific pulse pressure levels associated with increased risks for incident cardiometabolic diseases and mortality.

Original Source(s)

Pulse pressure and cardiometabolic disease progression: associations with incident multimorbidity and mortality in UK biobank

  • by Ting Lin, Shuai Hu, Wen Gong, Linqi Li, Zhaowei Zhu, Hebin Xie, Feijun Zhao

  • June 23, 2026

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