Pulse pressure and cardiometabolic disease progression: associations with incident multimorbidity and mortality in UK biobank

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The study analyzed 403,851 UK Biobank participants to assess the relationship between pulse pressure and cardiometabolic diseases.
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A 1-SD increase in pulse pressure was linked to a 13% higher risk of developing cardiometabolic diseases and an 18% higher risk of cardiometabolic multimorbidity.
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The strongest association between pulse pressure and cardiometabolic multimorbidity was observed in participants with stroke, showing a 23% increased risk.
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Subgroup analyses indicated that the pulse pressure-cardiometabolic multimorbidity association was most pronounced in individuals under 60 years and those with a BMI of 18.5 to 25 kg/m2.
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Threshold-effect analyses identified specific pulse pressure levels associated with increased risks for incident cardiometabolic diseases and mortality.

Frontiers In Cardiovascular Medicine

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