Authors’ Reply: Clarifying the Comparative Interpretation and Clinical Implications of Radiomics-Based AI for Pathological Response Prediction - Takeaways - MDSpire
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Response from Authors: Elucidating the Clinical Significance and Comparative Analysis of AI-Driven Radiomics for Predicting Pathological Responses

  • By

  • Ziqi Jiang

  • Yuan Xu

  • Shuyu Jia

  • Hongsheng Liu

  • October 6, 2026

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  • 1

    The authors addressed comments regarding their systematic review and meta-analysis on AI-driven radiomics for predicting pathological responses.

  • 2

    The analysis included validation cohorts, with AI showing greater sensitivity but conventional criteria demonstrating greater specificity.

  • 3

    No same-patient head-to-head studies currently exist to establish definitive superiority of AI over conventional criteria.

  • 4

    Pooled estimates reflect patients who underwent resection and should not be extrapolated to an intention-to-treat population.

  • 5

    Future studies should focus on multicenter validation and same-patient comparisons to clarify the utility of AI in clinical decision-making.

Original Source(s)

Authors’ Reply: Clarifying the Comparative Interpretation and Clinical Implications of Radiomics-Based AI for Pathological Response Prediction

  • by Ziqi Jiang, Yuan Xu, Shuyu Jia, Hongsheng Liu

  • October 6, 2026

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