Emergence of Severe and Prolonged Hepatobiliary Disorders Following COVID-19 Infection: A Systematic Analysis

By
Ali Aboulwafa
Ahamed Lebbe
Aya Khalil
Nuran Bayraktar
Beshr Mushannen
Sama Ayoub
Shaunak Sarker
Marwan Nour Abdalla
Sa’ad Laws
Ibrahim Mohammed
Lina Yagan
Malik Mushannen
Dalia Zakaria
February 4, 2026
0 min

Bmc Infectious Diseases

1

COVID-19 can lead to severe and prolonged hepatobiliary disorders, including cholangitis, cholecystitis, and hepatitis.
2

Liver injuries from COVID-19 may result from direct viral invasion or systemic inflammation, causing acute and chronic complications.
3

Long-COVID encompasses diverse symptoms and conditions that persist or develop at least four weeks post-infection.
4

The systematic review included 23 studies that reported severe hepatobiliary complications following COVID-19 infection.
5

Quality assessments of included studies were conducted using the Newcastle–Ottawa Scale and Murad et al.'s scale.

Original Source(s)

Bmc Infectious Diseases

Emergence of Severe and Prolonged Hepatobiliary Disorders Following COVID-19 Infection: A Systematic Analysis

by Ali Aboulwafa, Ahamed Lebbe, Aya Khalil, Nuran Bayraktar, Beshr Mushannen, Sama Ayoub, Shaunak Sarker, Marwan Nour Abdalla, Sa’ad Laws, Ibrahim Mohammed, Lina Yagan, Malik Mushannen, Dalia Zakaria
February 4, 2026

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