Prevalence and Contributing Factors of Hypothyroidism in Hematological Malignancy Patients Compared to Healthy Individuals: A Systematic Review and Meta-Analysis

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Hematological malignancies account for 6% of all cancers, with increasing incidence but declining death rates due to improved treatment understanding.
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Hypothyroidism is a common long-term endocrine complication in patients with hematological malignancies, particularly after certain treatments.
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Risk factors for hypothyroidism in hematological malignancy patients include type of malignancy, gender, and specific treatment regimens.
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Chemotherapy and radiotherapy can significantly increase the risk of developing hypothyroidism in patients with hematological malignancies.
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This systematic review aims to evaluate the incidence of hypothyroidism in hematological malignancy patients and identify contributing factors.

Bmc Cancer

by Zahra Moradi, Samaneh Toutounchian, Zahra Eghbali, Mahsa Barzegar, Dorsa Mohammadi, Dorsa Salabat, Niloofar Moradi, Maryam Barkhordar, Zahra Salehi
November 19, 2025

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