Association between maternal thyroid function and adverse outcomes of pregnant women and offspring: evidence from an umbrella review - Takeaways - MDSpire

Linking Maternal Thyroid Function to Negative Outcomes in Pregnant Women and Their Offspring: Insights from an Umbrella Review

  • By

  • Jiani Zhang

  • Yingying Chen

  • Guiqiong Huang

  • Chunyan Deng

  • Chihui Mao

  • Bingjie Li

  • Xiaodong Wang

  • Haiyan Yu

  • April 11, 2026

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  • 1

    Thyroid hormones are crucial for metabolism and fetal development, with abnormalities during pregnancy leading to significant health risks.

  • 2

    Uncontrolled thyroid dysfunction in pregnancy is linked to adverse outcomes such as miscarriage, preterm delivery, and neurodevelopmental deficiencies.

  • 3

    The relationship between gestational diabetes and thyroid diseases remains unclear, with inconsistent research findings on their associations.

  • 4

    This umbrella review aims to synthesize evidence on maternal thyroid dysfunction and its impact on pregnancy outcomes for better clinical decision-making.

  • 5

    Methodological quality and evidence certainty were assessed using AMSTAR 2 and GRADE approaches to evaluate the included meta-analyses.

Original Source(s)

Association between maternal thyroid function and adverse outcomes of pregnant women and offspring: evidence from an umbrella review

  • by Jiani Zhang, Yingying Chen, Guiqiong Huang, Chunyan Deng, Chihui Mao, Bingjie Li, Xiaodong Wang, Haiyan Yu

  • April 11, 2026

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