Successful management of metachronous dual primary esophageal carcinomas: first report of consecutive adenoid cystic carcinoma and squamous cell carcinoma with exceptional treatment outcome—a case report - Takeaways - MDSpire

Successful management of metachronous dual primary esophageal carcinomas: first report of consecutive adenoid cystic carcinoma and squamous cell carcinoma with exceptional treatment outcome—a case report

  • By

  • Yuxi Bai

  • Lidan Geng

  • Xiyue Yang

  • Qiuling Shi

  • Jie Li

  • Gang Feng

  • May 22, 2026

  • 0 min

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  • 1

    Esophageal adenoid cystic carcinoma (ACC) is a rare malignancy, constituting 0.04%–0.16% of esophageal cancers.

  • 2

    A 58-year-old male developed metachronous squamous cell carcinoma (SCC) after treatment for esophageal ACC.

  • 3

    The SCC was located outside the radiation field and was successfully treated with definitive chemoradiotherapy.

  • 4

    Postoperative radiotherapy for ACC was well tolerated, with only Grade 1 esophagitis and fatigue reported.

  • 5

    The case highlights the importance of comprehensive endoscopic surveillance for early detection of secondary malignancies.

Original Source(s)

Successful management of metachronous dual primary esophageal carcinomas: first report of consecutive adenoid cystic carcinoma and squamous cell carcinoma with exceptional treatment outcome—a case report

  • by Yuxi Bai, Lidan Geng, Xiyue Yang, Qiuling Shi, Jie Li, Gang Feng

  • May 22, 2026

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