Oxidative stress markers in bipolar disorder and first-degree relatives: differential associations of ischemia-modified albumin and superoxide dismutase

1

This study evaluated oxidative stress markers in bipolar disorder (BD) patients, their unaffected first-degree relatives (FDRs), and healthy controls (HCs).
2

Ischemia-modified albumin (IMA) levels were significantly higher in BD patients compared to HCs, indicating potential disease-related oxidative stress.
3

Superoxide dismutase (SOD) levels were elevated in both BD patients and FDRs, suggesting a possible association with familial vulnerability to BD.
4

Thiol-disulfide homeostasis (TDH) differences between BD and FDR groups were not significant after adjusting for age, which emerged as a major determinant.
5

Receiver operating characteristic analyses showed modest discriminative performance for IMA and SOD as biomarkers of oxidative stress in BD.

Frontiers In Psychiatry

by Ece Buyuksandalyaci Tunc, Burcu Kok Kendirlioglu, Hidayet E. Arat-Çelik, Esma Corekli Kaymakci, Serhat Tunc, Suat Kucukgoncu, Salim Neselioglu, Ozcan Erel
June 26, 2026

1